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Author: Pano Savvidis - Organic Lifestyle Magazine Author: Pano Savvidis - Organic Lifestyle Magazine

Can Exercise Change Our DNA?

We all know that exercise is good for our bodies. We’ve known it from our earliest school days when we were encouraged to take up sports and stay active. However, what many of us don’t know is just how deep this positive impact can go.

New research suggests exercise could have an effect that’s as far-reaching as our DNA. Rather than just honing our muscles and reducing our risk of illness, exercise could actually be changing the shape and functioning of our genes in a complex and dynamic manner.

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The Study of Epigenetics

The human genome is fascinating. Far from being static, it experiences a continuous cycle of change, with genes constantly turning themselves on and off in response to biochemical signals from the body. The easiest way to understand this is to imagine these genes as traffic lights. When the green light is on, proteins are released, catalysing physiological responses throughout the body.

It has long been understood that exercise can cause these “traffic lights” to switch on or off, becoming more or less active as it impacts the body. However, the exact cause of these fluctuations had always remained a mystery until the study of epigenetics. Epigenetics refers to a process whereby the DNA remains unaltered, yet the operation of the gene is changed. These modifications occur on the outside of the gene, via an event called methylation. This is where methyl groups – essentially clusters of atoms – attach to the exterior of the structure much like molluscs on a rock. As a result, the gene is rendered more or less able to receive and respond to the biochemical signals it receives.

The Effect of Exercise on Methylation Patterns

One of the main catalysts for changing methylation patterns is lifestyle. This means that environmental factors, from certain food types to chemicals that we’re exposed to, can cause these ‘traffic lights’ to become more or less likely to show green or red in response to stimuli, thus affecting the likelihood of certain proteins being expressed. Depending on the exact changes that take place, this can affect our health or our chances of developing some diseases.

The exact impact of exercise had not been fully explored until recently. Interestingly, the first tentative research suggested that a single bout of exercise was capable of causing immediate changes to methylation patterns of some of the genes in our muscle cells. It’s thanks to these findings that scientists from the Karolinska Institute in Stockholm were inspired to carry out a more in-depth study into the effect of long-term physical training on gene structures.1

The Karolinska Study

The scientists in Stockholm decided to answer their questions with a specially formulated study. They recruited 23 young men and women and asked them to undergo a series of physical performance and medical tests in a laboratory environment. They were then asked to go away and exercise their lower bodies for a period of three months.

In order to rule out other environmental causes for altered methylation patterns, it was requested that they only exercise one leg so that the two limbs could be compared.  Each participant became both a test subject and a member of the control group.

The changes discovered within the cell structures were intriguing. Genomic analysis revealed more than 5,000 altered methylation patterns in the genomes of the muscle cells they biopsied.

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A large number of these changes were on parts of the genome known as enhancers, which are responsible for exaggerating the expression of proteins by genes. Most were identified as influencing energy metabolism, insulin response, and muscle inflammation i.e. the level of health for the muscle.

What Does This Mean?

Although further research will be required to fully understand the impact of exercise on our genes, the message should be enough to encourage all of us to review our lifestyles. As Malene Lindholm, one of the progenitors of the study so succinctly puts it, “Through endurance training  – a lifestyle change that is easily available for most people and doesn’t cost much money – we can induce changes that affect how we use our genes and, through that, get healthier and more functional muscles, which ultimately improve our quality of life.”

Could it be time to break out your exercise gear and step your fitness regime up a notch?

Contributor’s Recommended Products:

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Further Reading:
Sources:
  1. An integrative analysis reveals coordinated reprogramming of the epigenome and the transcriptome in human skeletal muscle after training – NCBI
  2. Long-term endurance training impacts muscle epigenetics – Karolinska Institutet



How To Build Your Own Polytunnel to Grow Food All Year

Polytunnels seem to be popping up all over the place – and with good reason! They’re a fantastic gardening tool that can increase crop size, extend the growing season, and protect your plants from the elements. And, you get all of these benefits without the hassle that comes with erecting a permanent structure such as a greenhouse. Around 90% of people who purchase pre-made polytunnels choose to erect them themselves, because it’s incredibly simple to do, and can save a significant chunk of cash compared to hiring a handyman or builder to do it for you. So here’s an easy guide to walk you through the process of building your very own polytunnel.

What Is a Polytunnel?

Basically speaking a polytunnel is constructed from a metal-framed semi-circular tunnel covered in hardwearing polythene with UV inhibitors to maximize its lifetime. A large amount of air is enclosed by a polytunnel, so it stays warm much longer than a greenhouse – and also does not suffer from such dramatic temperature fluctuations in summer. During the winter you can regulate temperature and maintain heat very simply by lining the inside of the tunnel with bubble wrap and then removing it in spring. The polythene film has a lifespan of between five and ten years, but the cost to replace it will be only 15%-20% of the cost of the original tunnel.

Lay the Foundations

As with building any structure, you need to start by laying the foundations. Correctly placed foundation tubes are absolutely vital to the safety and longevity of your tunnel, so it’s crucial to get this step right. Start by marking the base positions around the site of the polytunnel – these will form the outline of the tunnel and will provide the base structure for you to build your aluminum frame. You should make sure the positions are evenly spaced and that the corners are at right angles, otherwise your tunnel might not be stable. You should then simply drive the foundation tubes into the ground at those marked positions. You can do this with a large hammer – but make sure to place a wooden block between the hammer and the tops of the tubes to avoid damaging or distorting them. You can either use tubes provided in a pre-fabricated polytunnel kit, or if building your own tunnel from scratch, offcuts of scaffolding poles or mains water pipe provide the perfect inexpensive substitute.  These should be cut to about six feet in length and driven into the ground to a depth of about three feet, depending on your desired polytunnel size. The bigger the tunnel the deeper the poles should go. Once they’re securely in the ground, check to be sure the tubes are level with a spirit level.
Building a Polytunnel  - foundations

Build the Frame

Whether you’re constructing a pre-fabricated polytunnel or building one from scratch, you’ll need a series of aluminum hoops to make up the frame of your tunnel. To build the frame, simply connect the hoops together (they generally come in multiple sections) and simply slide them over the foundation tubes, bolting each in place. Finally, fit the ridge pole down the centre top of the tunnel, corner bracing and doorframes. Check that the hoops are all straight and in line, then tighten all the joints carefully.

Building a Polytunnel - structureAdd the Cover

Now your framework is securely in place, it’s time to attach the cover and add the ‘poly’ to your tunnel. Most pre-fabricated polytunnels will come with some sort of cushioning to put over the hoops, to ensure the polythene sheet doesn’t snag or tear – but if you’re building one from scratch you can use foam coverings or anti hot-spot tape (which can be sourced from larger garden stores). This isn’t absolutely vital, but will increase the lifespan of the sheet by around a year – so it’s a good investment. Clear any stones from the ground around your frame and unroll the cover, sliding it over the hoops so it sits evenly over the frame. To secure it you can either attach it to the base rail if you have one (as most pre-made kits will), or  simply bury a skirt of polythene in a trench approximately 30cm deep. If your model is supplied without a base rail, but you don’t have space to dig a trench, you can make one using lengths of 70 x 45mm timber, cut to length, then bolted on to the foundation tubes. Whichever you choose it’s important to keep the plastic sheet as taut as possible during fitting. Now simply either cut a V shape in the sheet where you’d like the entrance to be, or use whichever door system is provided in your kit. There you have it, your very own polytunnel!

Be sure to check out our website, premierpolytunnels.co.uk
Building a Polytunnel